Two Postdoctoral Positions in Computational Biology
The computational laboratory of Terry Furey in the Institute for Genome Sciences & Policy (IGSP) at Duke University in North Carolina seeks two postdoctoral fellows interested in large-scale genomic research. Our group has been working with the experimental laboratory of Greg Crawford, also in the IGSP at Duke, to identify and analyze the relationship between chromatin structure and gene regulation. This work is centered on the generation and analysis of high-throughput data using both next-generation sequencing technologies and genomic expression microarrays.
More specifically, the two positions are as follows:
1) Identifying and characterizing open chromatin in 15-20 distinct cell lines. As part of the NIH-funded ENCODE consortium, the Furey and Crawford labs have teamed with laboratories of Jason Lieb at UNC-Chapel Hill, Vishy Iyer at UT-Austin, and Ewan Birney at the EBI to employ sequencing and microarray technologies to identify and explore open chromatin and gene regulation using DNaseI hypersensitivity (HS), FAIRE, ChIP, and gene expression experiments. This position will be responsible for developing methods and software for analyzing these high-throughput data as well as participating in the biological analyses, interpretation, and comprehensive integration of these and other genome-wide data types generated by us and other ENCODE consortium labs.
2) Identifying and characterizing gene expression and open chromatin in multiple primate species. As part of a collaboration with the Crawford lab and the lab of Greg Wray, also in the IGSP at Duke University, next-generation sequencers will be used to generate expression tag sequences and DNaseI HS data from similar cell types across multiple primates to explore changes in gene regulation and chromatin structure. This position will be responsible for developing methods and software for the analyses of these data including participating in the biological analyses as well.
Candidates for both positions should have obtained or will be obtaining a Ph.D. in
computational biology, computer science, or a similar discipline. Familiarity with the linux operating system and extensive programming experience is required. Past research in human gene regulation and/or chromatin structure is highly desired. Interested individuals should send a CV, a summary of research experience, and sample programs to Terry Furey at terry.furey@duke.edu for consideration.