Elena Edelman
Elena Edelman, 5th Year PhD Student
Advisor: Sayan Mukherjee
Email: eje2(at)duke.edu
Hometown: Bethesda, MD, USA
Location: CIEMAS
Education
Duke University
Bachelor of Science, Math
Bachelor of Arts, Biology
Research Interests
The first part of my research has been to develop a method that quantifies molecular perturbations between groups at the pathway level. Unlike studying gene expression data at the single gene level, pathway analysis allows for greater biological insight into what is truly occurring in an individual with a particular disease and better directs treatment for the individual. I am extending the idea of pathways analysis into the study of cancer dynamics, focusing on modeling pathways alterations in the initiation and progression of cancer. I have been working on pathway models of progression in prostate cancer, melanoma, and colorectal cancer and begun to identify pathways associated with the diseases that can potentially act as new therapeutic targets.
Publications
Edelman EJ, Guinney J, Chi JT, Febbo PG, Mukherjee S. Modeling Cancer Progression via Pathway Dependencies. PLoS Comput Biol. 2008 Feb 15;4(2):e28 [Epub ahead of print] pubmed link
Edelman E, Porrello A, Guinney J, Balakumaran B, Bild A, Febbo PG, Mukherjee S. Analysis of sample set enrichment scores: assaying the enrichment of sets of genes for individual samples in genome-wide expression profiles. Bioinformatics. 2006 Jul 15;22(14):e108-16. pubmed link
Outside Interests/Hobbies
Walking with my dog, scuba diving, working out, watching Duke basketball.