My research involves identifying gene regulatory elements across the genome to help us understand how chromatin structure dictates cell function and fate.
Greg Crawford, Ph.D. is an Assistant Professor in the Department of Pediatrics and the IGSP. He received his Ph.D from the University of Michigan in 2001. Afterwards, he was a post-doctoral fellow in the lab of Dr. Francis Collins at the National Human Genome Research Institute, where he developed novel technologies to identify active gene regulatory elements on a genome-wide scale. He joined the Duke faculty in March 2006.
My research involves identifying gene regulatory elements across the genome to help us understand how chromatin structure dictates cell function and fate. For the last 25 years, mapping DNase I hypersensitive sites has been the gold standard method to identify the location of active regulatory elements, including promoters, enhancers, silencers, and locus control regions. I have developed two technologies that can identify most DNase I hypersensitive sites from potentially any cell type from any species with a sequenced genome. These data can be combined with other wet-lab and computational data types to better understand how these regulatory regions control global gene expression.
Degner JF, Pai AA, Pique-Regi R, Veyrieras JB, Gaffney DJ, Pickrell JK, De Leon S, Michelini K, Lewellen N, Crawford GE, Stephens M, Gilad Y, Pritchard JK, Nature. 2012 Feb 5;. Abstract
Reddy TE, Gertz J, Pauli F, Kucera KS, Varley KE, Newberry KM, Marinov GK, Mortazavi A, Williams BA, Song L, Crawford GE, Wold BJ, Willard HF, Myers RM, Genome Res. 2012 Feb 2;. Abstract
Gaffney DJ, Veyrieras JB, Degner JF, Roger PR, Pai AA, Crawford GE, Stephens M, Gilad Y, Pritchard JK, Genome Biol. 2012 Jan 31;13(1):R7. Abstract
Bischof JM, Ott CJ, Leir SH, Gosalia N, Song L, London D, Furey TS, Cotton CU, Crawford GE, Harris A, Thorax. 2011 Dec 14;. Abstract
Zhang W, Wu Y, Schnable JC, Zeng Z, Freeling M, Crawford GE, Jiang J, Genome Res. 2012 Jan;22(1):151-62. Abstract
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