David Goldstein, PhD

David Goldstein, The Richard and Pat Johnson Distinguished University Professor, is Director of the Center for Human Genome Variation and Professor of Molecular Genetics & Microbiology and Biology at Duke University School of Medicine. Dr. Goldstein is the author of over 200 scholarly publications in the areas of population and medical genetics. His principal interests include human genetic diversity, the genetics of disease, and pharmacogenetics. In April 2007, he was appointed Honorary Professor, Institute of Neurology, University College London, UK. He is the recipient of one of the first seven nationally awarded Royal Society / Wolfson research merit awards in the UK for his work in human population genetics. Most recently, he was appointed chair of the Gordon Research Conference meeting on human genetics and genomics for 2013.

A genome-wide association study of resistance to HIV infection in highly exposed uninfected individuals with hemophilia A.

Lane J, McLaren PJ, Dorrell L, Shianna KV, Stemke A, Pelak K, Moore S, Oldenburg J, Alvarez-Roman MT, Angelillo-Scherrer A, Boehlen F, Bolton-Maggs PH, Brand B, Brown D, Chiang E, Cid-Haro AR, Clotet B, Collins P, Colombo S, Dalmau J, Fogarty P, Giangrande P, Gringeri A, Iyer R, Katsarou O, Kempton C, Kuriakose P, Lin J, Makris M, Manco-Johnson M, Tsakiris DA, Martinez-Picado J, Mauser-Bunschoten E, Neff A, Oka S, Oyesiku L, Parra R, Peter-Salonen K, Powell J, Recht M, Shapiro A, Stine K, Talks K, Telenti A, Wilde J, Yee TT, Wolinsky SM, Martinson J, Hussain SK, Bream JH, Jacobson LP, Carrington M, Goedert JJ, Haynes BF, McMichael AJ, Goldstein DB, Fellay J, for the NIAID Center for HIV/AIDS Vaccine Immunology (CHAVI), Hum Mol Genet. 2013 Jan 30;. Abstract

Mutation in TECPR2 Reveals a Role for Autophagy in Hereditary Spastic Paraparesis.

Oz-Levi D, Ben-Zeev B, Ruzzo EK, Hitomi Y, Gelman A, Pelak K, Anikster Y, Reznik-Wolf H, Bar-Joseph I, Olender T, Alkelai A, Weiss M, Ben-Asher E, Ge D, Shianna KV, Elazar Z, Goldstein DB, Pras E, Lancet D, Am J Hum Genet. 2012 Dec 7;91(6):1065-72. Abstract

Novel mutation in VCP gene causes atypical amyotrophic lateral sclerosis.

González-Pérez P, Cirulli ET, Drory VE, Dabby R, Nisipeanu P, Carasso RL, Sadeh M, Fox A, Festoff BW, Sapp PC, McKenna-Yasek D, Goldstein DB, Brown RH, Blumen SC, Neurology. 2012 Nov 27;79(22):2201-2208. Abstract

Host Genetics of HIV Acquisition and Viral Control.

Shea PR, Shianna KV, Carrington M, Goldstein DB, Annu Rev Med. 2012 Sep 27;. Abstract

Limited contribution of common genetic variants to risk for liver injury due to a variety of drugs.

Urban TJ, Shen Y, Stolz A, Chalasani N, Fontana RJ, Rochon J, Ge D, Shianna KV, Daly AK, Lucena MI, Nelson MR, Molokhia M, Aithal GP, Floratos A, Pe'er I, Serrano J, Bonkovsky H, Davern TJ, Lee WM, Navarro VJ, Talwalkar JA, Goldstein DB, Watkins PB, Drug-Induced Liver Injury Network, DILIGEN, EUDRAGENE, Spanish DILI Registry, International Serious Adverse Events Consortium, Pharmacogenet Genomics. 2012 Nov;22(11):784-95. Abstract

more publications

IGSP Faculty

Professor, Department of Molecular Genetics and Microbiology

Recent Publications

A genome-wide association study of resistance to HIV infection in highly exposed uninfected individuals with hemophilia A.

Mutation in TECPR2 Reveals a Role for Autophagy in Hereditary Spastic Paraparesis.

Novel mutation in VCP gene causes atypical amyotrophic lateral sclerosis.

Host Genetics of HIV Acquisition and Viral Control.

Limited contribution of common genetic variants to risk for liver injury due to a variety of drugs.