Chromatin and DNA Replication.
Macalpine DM, Almouzni G, Cold Spring Harb Perspect Biol. 2013 Jun 10;. Abstract
IGSP Faculty
David M. MacAlpine, PhDDavid M. MacAlpine, PhD
Assistant Professor, Department of Pharmacology and Cancer Biology
Our laboratory is interested in understanding the mechanisms by which the molecular architecture of the chromosome regulates fundamental biological processes such as replication and transcription. Specifically, how are replication, transcription and chromatin modification coordinated on a genomic scale to maintain genomic stability? We are addressing this question by using genomic, computational and biochemical approaches in variety of model systems, including: Drosophila , yeast and mammalian cell culture.
Learn more about Dr. MacAlpine's research in GenomeLIFE
Recent Publications
Rare codons regulate KRas oncogenesis.
Lampson BL, Pershing NL, Prinz JA, Lacsina JR, Marzluff WF, Nicchitta CV, MacAlpine DM, Counter CM, Curr Biol. 2013 Jan 7;23(1):70-5. Abstract
Identification of E2F target genes that are rate limiting for dE2F1-dependent cell proliferation.
Herr A, Longworth M, Ji JY, Korenjak M, Macalpine DM, Dyson NJ, Dev Dyn. 2012 Nov;241(11):1695-707. Abstract
Genome-wide localization of replication factors.
Lubelsky Y, MacAlpine HK, MacAlpine DM, Methods. 2012 Jun;57(2):187-95. Abstract
Developmental control of gene copy number by repression of replication initiation and fork progression.
Sher N, Bell GW, Li S, Nordman J, Eng T, Eaton ML, Macalpine DM, Orr-Weaver TL, Genome Res. 2012 Jan;22(1):64-75. Abstract
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