IGSP Faculty

David M. MacAlpine, PhD

David M. MacAlpine, PhD

Associate Professor, Department of Pharmacology and Cancer Biology

Our laboratory is interested in understanding the mechanisms by which the molecular architecture of the chromosome regulates fundamental biological processes such as replication and transcription. Specifically, how are replication, transcription and chromatin modification coordinated on a genomic scale to maintain genomic stability? We are addressing this question by using genomic, computational and biochemical approaches in variety of model systems, including: Drosophila , yeast and mammalian cell culture.

Learn more about Dr. MacAlpine's research in GenomeLIFE

Recent Publications