E2F6 Associates with BRG1 in Transcriptional Regulation.
Leung JY, Nevins JR, PLoS One. 2012;7(10):e47967. Abstract
Dr. Joseph Nevins is Barbara Levine Professor of Breast Cancer Genomics. His research focuses on the gene regulatory events associated with the control of cellular proliferation and cell fate, including the dysregulation that contributes to oncogenesis. This work has specifically focused on the retinoblastoma tumor suppressor (Rb) and the role of this protein in controlling the E2F transcription factor activities. Additionally, work in the Nevins lab has focused on the interplay of cellular signaling pathways that in combination control cell proliferation including the role of Ras, Myc, and other activities. Finally, a major component of the effort in the lab focuses on the use of genome-scale measures of gene expression, employing DNA microarrays, to identify expression profiles that characterize oncogenic pathways and that define tumor phenotypes of importance in determining clinical outcomes.
Learn more about Dr. Nevins's research in GenomeLIFE
Leung JY, Nevins JR, PLoS One. 2012;7(10):e47967. Abstract
Angus SP, Nevins JR, Oncogene. 2012 Jan 16;. Abstract
Chang JT, Gatza ML, Lucas JE, Barry WT, Vaughn P, Nevins JR, BMC Bioinformatics. 2011;12:443. Abstract
Leung JY, Andrechek ER, Cardiff RD, Nevins JR, Oncogene. 2012 May 17;31(20):2545-54. Abstract
Wong JV, Dong P, Nevins JR, Mathey-Prevot B, You L, Cell Cycle. 2011 Sep 15;10(18):3086-94. Abstract
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