Dr. Joseph Nevins is Barbara Levine Professor of Breast Cancer Genomics. His research focuses on the gene regulatory events associated with the control of cellular proliferation and cell fate, including the dysregulation that contributes to oncogenesis. This work has specifically focused on the retinoblastoma tumor suppressor (Rb) and the role of this protein in controlling the E2F transcription factor activities. Additionally, work in the Nevins lab has focused on the interplay of cellular signaling pathways that in combination control cell proliferation including the role of Ras, Myc, and other activities. Finally, a major component of the effort in the lab focuses on the use of genome-scale measures of gene expression, employing DNA microarrays, to identify expression profiles that characterize oncogenic pathways and that define tumor phenotypes of importance in determining clinical outcomes.
Dressman HK, Berchuck A, Chan G, Zhai J, Bild A, Sayer R, Cragun J, Clarke J, Whitaker RS, Li L, Gray J, Marks J, Ginsburg GS, Potti A, West M, Nevins JR, Lancaster JM, J Clin Oncol. 2012 Feb 20;30(6):678. Abstract
Chang JT, Gatza ML, Lucas JE, Barry WT, Vaughn P, Nevins JR, BMC Bioinformatics. 2011;12:443. Abstract
Wong JV, Dong P, Nevins JR, Mathey-Prevot B, You L, Cell Cycle. 2011 Sep 15;10(18):3086-94. Abstract
LaBreche HG, Meadows SK, Nevins JR, Chute JP, PLoS One. 2011;6(8):e23043. Abstract
LaBreche HG, Nevins JR, Huang E, BMC Med Genomics. 2011;4:61. Abstract
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