Synthetic gene circuits that can precisely program cellular behavior have great potential for applications in biotechnology, computation, environmental engineering and medicine. We are exploring general and scalable control strategies that will allow us to realize robust gene circuit function despite cellular noise and external perturbations.

Open positions

We invite motivated individuals to join us in exciting research in synthetic and systems biology. Active projects include engineering of synthetic ecosystems, population-based mechanisms of antibiotic resistnace, bacterial killer circuits and microbial swarmbots for therapeutic applications, analysis and reprogramming of mammalian cell cycle, and information processing by gene circuits.

o       Lab technician: A B.S. in biology or related fields, familiar with microbiology and molecular biology techniques, including but not limited to preparation of chemical and biological reagents, cloning, bacterial culturing, and use of typical lab equipment.

o       Postdoc: Two postdoctoral positions are immediately available. In these projects, we use a synthetic-biology approach to examine the evolutionary dynamics of programmed cell death in bacteria and its implications for understanding bacterial responses to antibiotic treatment, the design principles underlying self organized pattern formation, and the impact of dispersal on the survival and maintenance of microbial communities. For these projects, we primarily use E. coli as the model organism. The ideal candidate should have recent PhD training in microbiology, evolutionary biology, physics, applied mathematics, or engineering. Relevant expertise includes experimental microbiology, quantitative modeling, and/or microfluidics.

If interested, send your CV to Lingchong You by email at you (at) duke.edu. Also arrange at least two recommendation letters. For a postdoc position, one letter should be from your current primary advisor.

 

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