Dongliang Ge, PhD
Dongliang’s main interest is in biostatistical and bioinformatical research for dissecting genetic contributors to human complex traits and their interactions.
- Biostatistical and bioinformatical software development
- Rare genetic variant annotation and analysis. Copy number variation annotation and analysis
- Large-scale biostatistical computation; parallel statistical computation
- Meta-analysis; survival analysis; longitudinal analysis
- Genomic, transcriptomic, and protemic analysis and annotations. -omics databases integration and application
Selected Publications
- Ge D, Fellay J, Thompson AJ, Simon JS, Shianna KV, Urban TJ, Heinzen EL, Qiu P, Bertelsen AH, Muir AJ, Sulkowski M, McHutchison JG, Goldstein DB. Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance. Nature. 2009 Aug 16.
- Ge D, Zhang K, Need AC, Martin O, Fellay J, Urban TJ, Telenti A, Goldstein DB. WGAViewer: Software for genomic annotation of whole genome association studies. Genome Res. 2008;18(4):640-3.
(Click here for the WGAViewer software) - Fellay J, Shianna KV *, Ge D *, Colombo S *, Ledergerber B *, Weale M *, Zhang K, Gumbs C, Castagna A, Cossarizza A, Cozzi-Lepri A, De Luca A, Easterbrook P, Francioli P, Mallal S, Martinez-Picado J, Miro JM, Obel N, Smith JP, Wyniger J, Descombes P, Antonarakis SE, Letvin NL, McMichael AJ, Haynes BF, Telenti A, Goldstein DB. A whole-genome association study of major determinants for host control of HIV-1. Science. 2007;317(5840):944-7. (* Equal authors)
- Heinzen E *, Ge D *, Cronin KD, Maia J, Shianna KV, Gabriel W, Welsh-Bohmer KA, Hulette CM, Denny T, Goldstein DB. Tissue specific genetic control of gene expression and alternative splicing: Implications for the study of human complex traits. PLoS Biol. 2008; 6(12): e1000001. (* Equal authors)
(Click here for the SNPExpress software) - Need AC *, Ge D *, Maia J, Shianna KV, Feng S, Strittmatter WJ, McEvoy JP, Keefe RSE, St Jean PL, Giegling I, Hartmann AM, Möller H, Ruppert A, Fraser G, Crombie C, Francks C, St.Clair D, Roses AD, Muglia P, Rujescu D, Goldstein DB. Multiple large deletions associated with chizophrenia. PLoS Genet. 2009; 5(2):e1000373.(* Equal authors)
- Pillai SG, Ge D, Zhu G, Kong X, Shianna KV, Need AC, S. F, Hersh CP, Bakkgators, Rennard SI, Lomas D, Silverman EK, Goldstein DB. A Genome-wide Association Study in Chronic Obstructive Pulmonary Disease (COPD): Identification of two Major Susceptibility Loci. PLoS Genet. 2009;In press.
- Stefansson H, Rujescu D, Cichon S, Pietilainen OP, Ingason A, Steinberg S, Fossdal R, Sigurdsson E, Sigmundsson T, Buizer-Voskamp JE, Hansen T, Jakobsen KD, Muglia P, Francks C, Matthews PM, Gylfason A, Halldorsson BV, Gudbjartsson D, Thorgeirsson TE, Sigurdsson A, Jonasdottir A, Jonasdottir A, Bjornsson A, Mattiasdottir S, Blondal T, Haraldsson M, Magnusdottir BB, Giegling I, Moller HJ, Hartmann A, Shianna KV, Ge D, Need AC, Crombie C, Fraser G, Walker N, Lonnqvist J, Suvisaari J, Tuulio-Henriksson A, Paunio T, Toulopoulou T, Bramon E, Di Forti M, Murray R, Ruggeri M, Vassos E, Tosato S, Walshe M, Li T, Vasilescu C, Muhleisen TW, Wang AG, Ullum H, Djurovic S, Melle I, Olesen J, Kiemeney LA, Franke B, Kahn RS, Linszen D, van Os J, Wiersma D, Bruggeman R, Cahn W, Germeys I, de Haan L, Krabbendam L, Sabatti C, Freimer NB, Gulcher JR, Thorsteinsdottir U, Kong A, Andreassen OA, Ophoff RA, Georgi A, Rietschel M, Werge T, Petursson H, Goldstein DB, Nothen MM, Peltonen L, Collier DA, St Clair D, Stefansson K. Large recurrent microdeletions associated with schizophrenia. Nature. 2008;455(7210):232-6.
- Price AL, Weale ME, Patterson N, Myers SR, Need AC, Shianna KV, Ge D, Rotter JI, Torres E, Taylor KD, Goldstein DB, Reich D. Long-range LD can confound genome scans in admixed populations. Am J Hum Genet 2008. 83(1):132-5; author reply 135-9.
- Cavalleri GL, Weale ME, Shianna KV, Singh R, Lynch JM, Grinton B, Szoeke C, Murphy K, Kinirons P, O'Rourke D, Ge D, Depondt C, Claeys KG, Pandolfo M, Gumbs C, Walley N, McNamara J, Mulley JC, Linney KN, Sheffield LJ, Radtke RA, Tate SK, Chissoe SL, Gibson RA, Hosford D, Stanton A, Graves TD, Hanna MG, Eriksson K, Kantanen AM, Kalviainen R, O'Brien TJ, Sander JW, Duncan JS, Scheffer IE, Berkovic SF, Wood NW, Doherty CP, Delanty N, Sisodiya SM, Goldstein DB. Multicentre search for genetic susceptibility loci in sporadic epilepsy syndrome and seizure types: a case-control study. Lancet Neurol. 2007;6(11):970-80.
Presentations
- "HIV Host Genomics Hands-on-Computer Workshop", Feb 2008, The 15th Conference on Retroviruses and Opportunistic Infections (CROI 2008), Boston, MA.
- The 57th American Society of Tropical Medicine and Hygiene (ASTMH) pre-annual meeting course on genome wide association studies, Dec 6, 2008, New Orleans, LA.