Erin Heinzen, PhD
Erin's main area of interest is in neuropsychiatric genomics. Studies involve investigations of the impact of single nucleotide polymorphisms and gene copy number variation on epilepsy and Alzheimer's disease predisposition, with direct determination of the effects of associated genetic variants on the brain transcriptome.
Selected Publications
- Heinzen EL*, Ge D*, Cronin KD, Maia JM, Shianna KV, Gabriel WN, Welsh-Bohmer KA, Hulette CM, Denny TN, Goldstein DB. Tissue-specific genetic control of splicing: Implications for the study of complex traits. PLoS Biol. 2008; 6(12): e1000001.
- Heinzen EL, Yoon W, Weale ME, Wood NW, Sen A, Burke JR, Welsh-Bohmer KA, Hulette CM, Sisodiya SM, Goldstein DB. Alternative ion channel splicing in mesial temporal lobe epilepsy and Alzheimer’s disease. Genome Biology. 2007; 8: R32.
- Heinzen EL, Yoon W, Tate SK, Sen A, Wood NW, Sisodiya SM, Goldstein DB. NOVA2 interacts with a cis-acting polymorphism to influence the proportions of pharmacologically relevant splice variants. American Journal of Human Genetics 2007; 80: 876-883.
Presentations
- Affymetrix Integrated Genomics Seminar Series, Duke University and University of North Carolina at Chapel Hill, June 2008.
- Cambridge Healthtech Institute, New applications for microarray data analysis, Integrating genetics with “omics”, Washington, DC, July 2007.
- Bryan Alzheimer’s Disease Research Center Seminar Series, Duke University, November 2006.
- Invited speaker for Splicing 2006 annual symposium, Bethesda, MD, September 2006.