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Anna Christina Need, PhD

Anna Christina Need, PhD

 

My research is primarily focused on how genetic variation affects behavior and cognition both in healthy subjects and in patients with schizophrenia.

 

 

 

Publications

  • Need AC*, Ge D*, Weale ME*, Maia J, Feng S, Heinzen EL, Shianna KV, Yoon W, Kasperaviciute. D, Gennarelli M, Strittmatter WJ, Bonvicini C, Rossi G, Jayathilake K, Coler P, McEvoy JP, Keefe RSE, Fisher EMC, St Jean PL, Giegling I, Hartmann AM, Möller H, Ruppert A, Fraser G, Crombie C, Middleton L, St.Clair D, Roses AD, Muglia P, Francks C, Rujescu D, Meltzer HY, Goldstein DB. A Genome-Wide Investigation of SNPs and CNVs in Schizophrenia. PLoS Genet. 2009 Feb;5(2):e1000373.
  • Need AC , Keefe RSE, McEvoy JP, Ge D, Grossman I, Dickson S & Goldstein DB. Pharmacogenetics of antipsychotic response in the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE). In press at European Journal of Human Genetics.
  • Need AC, Kasperaviciute D, Cirulli ET & Goldstein DB. A Genome-Wide Genetic Signature of Jewish Ancestry perfectly separates Individuals with and without Full Jewish Ancestry in a Large Random Sample of European Americans. In press at Genome Biology.
  • Pillai SG, Ge D, Guohua Z, Kong X, Shianna KV, Need AC, Hersh CP, Bakke P, Gulsvik A, Ruppert, Lødrup Carlsen KC, Roses A, Anderson W, ICGN Investigators, Rennard SI, Lomas D, Silverman EK and Goldstein DB. A Genome-wide Association Study in Chronic Obstructive Pulmonary Disease (COPD): Identification of two Major Susceptibility Loci. In press at PLoS Genetics.
  • Stefansson H, Rujescu D, Cichon S, Pietiläinen OP, Ingason A, Buizer-Voskamp JE, Hansen T, Jakobsen KD, Muglia P, Francks C, Matthews PM, Gylfason A, Halldorsson BV, Gudbjartsson D, Thorgeirsson TE, Sigurdsson A, Jonasdottir A, Jonasdottir A, Bjornsson A, Mattiasdottir S, Blondal T, Haraldsson M, Magnusdottir BB, Giegling I, Möller HJ, Hartmann A, Shianna KV, Ge D, Need AC, Crombie C, Fraser G, Walker N, Lonnqvist J, Suvisaari J, Tuulio-Henriksson A, Paunio T, Toulopoulou T, Bramon E, Di Forti M, Murray R, Ruggeri M, Vassos E, Tosato S, Walshe M, Li T, Vasilescu C, Mühleisen TW, Wang AG, Ullum H, Djurovic S, Melle I, Olesen J, Kiemeney LA, Franke B; GROUP, Sabatti C, Freimer NB, Gulcher JR, Thorsteinsdottir U, Kong A, Andreassen OA, Ophoff RA, Georgi A, Rietschel M, Werge T, Petursson H, Goldstein DB, Nöthen MM, Peltonen L, Collier DA, St Clair D, Stefansson K. Large recurrent microdeletions associated with schizophrenia. Nature. 2008 Sep 11;455(7210):232-6.
  • Price AL, Weale ME, Patterson N, Myers SR, Need AC, Shianna KV, Ge D, Rotter JI, Torres E, Taylor KD, Goldstein DB, Reich D. Long-range LD can confound genome scans in admixed populations. Am J Hum Genet. 2008 Jul;83(1):132-5.
  • Ge D, Zhang K, Need AC, Martin O, Fellay J, Urban TJ, Telenti A, Goldstein DB. WGAViewer: software for genomic annotation of whole genome association studies. Genome Res. 2008 Apr;18(4):640-3.
  • Eickholt BJ, Ahmed AI, Davies M, Papakonstanti EA, Pearce W, Starkey ML, Bilancio A, Need AC, Smith AJ, Hall SM, Hamers FP, Giese KP, Bradbury EJ, Vanhaesebroeck B. Control of Axonal Growth and Regeneration of Sensory Neurons by the p110delta PI 3-Kinase.PLoS ONE. 2007 11;2(9):e869.
  • Goldstein DB, Need AC, Singh R, Sisodiya SM. Potential genetic causes of heterogeneity of treatment effects. Am J Med. 2007 S21-5.
  • Sisodiya SM, Thompson PJ, Need A, Harris SE, Weale ME, Wilkie SE, Michaelides M, Free SL, Walley N, Gumbs C, Gerrelli D, Ruddle P, Whalley LJ, Starr JM, Hunt DM, Goldstein DB, Deary IJ, Moore AT.Genetic enhancement of cognition in a kindred with cone-rod dystrophy due to RIMS1 mutation. J Med Genet. 2007 44(6):373-80.
  • Need AC, Goldstein DB. Genome-wide tagging for everyone. Nat Genet. 2006 38(11):1227-8.
  • Need AC, Ahmadi KR, Spector TD, Goldstein DB. Obesity is associated with genetic variants that alter dopamine availability. Ann Hum Genet. 2006 70:293-303.
  • Need AC, Motulsky AG, Goldstein DB. Priorities and standards in pharmacogenetic research. Nat Genet. 2005 37(7):671-81.
  • Need AC, Irvine EE, Giese KP. Learning and memory impairments in Kv.1.1-null mutants are rescued by environmental enrichment or ageing. Eur J Neurosci. 2003 18(6):1640-4.
  • Need AC, Giese KP. Handling and environmental enrichment do not rescue learning and memory impairments in .CamKIIT286A mutant mice. Genes Brain Behav. 2003 2(3):132-9 .