Uwe Ohler's Research Group
Collaborations & Funding
The broad focus of the group is on:
- RE-gulation: integration and cross-talk between different steps in transcriptional and post-transcriptional events;
- CO-nservation and comparative genomics of gene regulation;
- DE-velopment of complex organisms and gene regulation.
Recent and ongoing collaborations give a good impression of what's going on. Starring in alphabetical order:
- Philip Benfey, Duke:
High-throughput imaging of gene expression in Arabidopsis root development
(Todd Twigg) - Bryan Cullen, Duke:
Prediction of host targets of viral microRNAs
(Eva Gottwein) - Alex Hartemink, Duke:
Motif finding with Bayesian approaches
(Raluca Gordan) - Jim Kadonaga, UCSD:
Validation of core promoter elements in Drosophila
(Tamar Juven) - Jack Keene, Duke:
Post-transcriptional regulation with RNA-binding proteins
(Neel Mukherjee) - Ilya Ruvinsky, U Chicago:
Regulation of neuronal gene expression in C elegans - Pavel Tomancak, MPI Dresden:
Embryonic expression patterns in Drosophila - Jun Zhu, Duke:
Identification of transcription start sites by high-throughput sequencing
Current External Funding:
We acknowledge the following funding sources who have provided us with funding to undertake our research projects:
- National Human Genome Research Institute (NHGRI): Modeling the structure & evolution of regulatory regions in eukaryotic gemomes (Fred Dietrich and Jim Kadonaga, co-PIs)
- National Institute of General Medical Sciences (NIGMS): co-PI on the Duke National Center for Systems Biology (Philip Benfey PI)
- National Science Foundation: Arabidopsis 2010 grant, Identifying transcriptional networks at cellular resolution (Philip Benfey PI, Rob Clark co-PI)
- National Science Foundation: Genome-wide exploration of miRNA-mediated network motifs (Jun Zhu, PI)
- Human Frontiers in Science Program (HFSP): Young Investigator award on Quantitative modeling of expression pattern evolution in insect development (Casey Bergman, Pavel Tomancak, co_PIs)
Past Funding:
- Alfred P Sloan Foundation: Scholar in computational molecular biology (2005-2007)