The Sullivan Lab is located at Duke University
Medical Center in Durham, NC. We are part of the Department
of Molecular Genetics and Microbiology and the Institute
for Genome Sciences & Policy.
Our lab is interested in how chromosomes are epigenetically
organized into inherited chromatin domains. Normal chromosome structure
and inheritance is essential for cell viability, health, and reproduction.
Defects in chromosomal processes lead to aneuploidy (deviation from
normal chromosome number), a feature of many birth defects and cancers.
The centromere is an important chromosomal locus that ensures chromosome and genome stability. We use multiple approaches (genetics, cell biology, molecular biology, genomics) to study functional elements of chromosomes, such as centromeres and telomeres, as well as DNA structure and chromatin organization at genomic regions that are prone to breakage and rearrangement.
Our research is funded by the National
Institutes of Health (NIH) and the March
of Dimes. |
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