Geoffrey S. Ginsburg, MD, PhD
Papers
1. Fry AJ, Ginsburg GS, and Parente R. (1978) Reduction of αlpha, alpha’-dibromoketones by ultrasonically dispersed mercury in ketone solvents: A convenient synthesis of 4-isopropylident-1, 3-dioxolanes. Chem Commun 1040-1041.
2. Fry AJ, Donaldson WA, and Ginsburg GS. (1979) Reductive acetoxylation of alpha,alpha’ dibromocycloalkanones by ultrasonically dispersed mercury. J. Org Chem 44:349-352.
3. Fry AJ and Ginsburg GS. (1979) Stereoelectronic control in the electrochemical and mercury promoted reductive acetoxylation of alpha,alpha’-dibromobicycloalkones. J. Amer Chem Soc 101:3927-3932.
4. Ginsburg GS and Small DM. (1981) Physical Properties of cholesteryl esters having 20 carbons or more. Biochem Biophys Acta – Lipids 664:98-107. PMID: 7236700
5. Ginsburg GS, Small DM, and Atkinson D. (1982) Microemulsions of phospholipids and cholesterol esters: Protein-free models of low density lipoprotein. J Biol Chem 257:8216-8227. PMID: 7085667
6. Ginsburg GS, Small DM, and Hamilton JA. (1982) Temperature-dependent molecular motions of cholesterol testers: A carbon 13-nuclear magnetic resonance study. Biochemistry 21:6857-6867. PMID: 7159569
7. Ginsburg GS, Atkinson D, and Small DM. (1984) Physical properties of cholesterol esters. Prog Lipid Res 23:135-167. PMID: 6399750
8. Ginsburg GS, Walsh M, Small DM, and Atkinson D. (1984) Synthetic models of plasma low density lipoproteins: Phospholipids-cholesterol ester-apoprotein B complexes. J Biol Chem 259:66676673. PMID: 6725265
9. Ginsburg GS, Safran C, and Pasternak RC. (1991) Frequency of Low Serum High Density Lipoprotein Cholesterol Levels in Hospitalized Patients with "Desirable" Total Cholesterol Levels. Am J Cardiol 68:187-192. PMID: 2063780
10. Mietus-Snyder M, Sladek F, Ginsburg GS, Kuo F, Darnell JE, and Karathanasis SK. (1992) Antagonism Between RP-1, Ear 3/COUP-TF and HNF-4 Modulates Apolipoprotein C-III Gene Expression in Liver and Intestinal Cells. Mol Cell Biol 12:1708-1718. PMID: 1312668
11. Silverman DI, Ginsburg GS, and Pasternak RC. (1993) HDL subfractions: Structure, Metabolism, and Epidemiology. Am. J. Med. 94:636-645. PMID: 8506891
12. Oettgen JP, Ginsburg GS, and Pasternak RL. (1994) Frequency of Hypothyroidism in Adults with Serum Cholesterol Levels > 200 mg/dl. Am J Cardiol 73:955-957. PMID: 8184852
13. Leidig GA, Pasternak RC, Horowitz G, and Ginsburg GS. (1994) Effects of Heparin and Cardiac Catheterization on Serum Lipoprotein and Triglyceride Levels. Am J Cardiol 74:47-52. PMID: 8017305
14. Ginsburg GS, Ozer J, and Karathanasis SK. (1995) Intestinal Apolipoprotein AI Gene Transcription Is Regulated by Multiple Distinct DNA Elements and Is Synergistically Activated by the Orphan Nuclear Receptor, Hepatocyte Nuclear Factor 4. J Clin Invest 96:528-538. PMID: 7615825
15. Gaudet F and Ginsburg GS. (1995) Transcriptional regulation of Cholesteryl Ester Transfer Protein Gene Expression by the Orphan Nuclear Hormone Receptor Apolipoprotein AI Regulatory Protein-1. J Biol Chem. 270:29916-29922. PMID: 8530390
16. Douglas PS and Ginsburg GS. (1996) Evaluation of Chest Pain in Women: An Evidence-Based Approach. N. Eng. J. Med. 334:1311-1315. PMID: 8609950
17. Harris N, Newburger J, Ticho B, Neufeld E, Baker A, Ginsburg GS, Rimm E, and Rifai N. (1996) Analytical performance and Clinical Utility of the Direct LDL Cholesterol Assay in a Hyperlipidemic Pediatric Population. Clin Chemistry. 42:1182-1188. PMID: 8697574
18. Satler CA, Walsh E, Vesely M, Plummer MH, Ginsburg GS, and Jacob H. (1996) Novel Missense Mutation in the Cyclic Nucleotide-Binding Domain of HERG Causes Long QT Syndrome. Amer J. Med Genet. 65:27-35. PMID: 8914737
19. Ginsburg GS, Amad, A, O'Toole M, Rimm E, Douglas PS, Rifai N. (1996) Single Bout of Exercise Alters Lipids, Lipoproteins, and Susceptibility to Peroxidation in Ironman Triathletes. JAMA 276:221-225. PMID: 8667567
20. Ginsburg GS and Douglas PS. (1996) Why Cardiologists Should be Interested in Estrogen. Am J Cardiology. 78: 559-561. PMID: 8806343
21. Oettgen P, Ginsburg GS. (1996) Cardiac Rehabilitation: Implementing a Four-phase Wellness/Risk Reduction Program. J. Crit. Ill. 11:710-719.
22. Naganawa S, Ginsberg H, Glickman RM and Ginsburg GS. (1997) Intestinal Transcription and Synthesis of Apolipoprotein AI is Regulated by Five Polymorphisms Upstream of the Apolipoprotein CIII Gene. J. Clin. Invest. 99:1958-1965. PMID: 9109440
23. Joffe II, Riley MF, Katz SE, Ginsburg GS, Douglas PS. (1997) Acquired dynamic left ventricular outflow tract obstruction complicating acute myocardial infarction: serial echocardiographic and clinical evaluation. J Am Soc Echocardiogr 10:717-721.PMID: 9339422
24. Douglas PS, O’Toole ML, Katz SE, Ginsburg GS, Hiller WDB, Laird RH. (1997) Left ventricular hypertrophy in athletes. Am J Cardiol 80:1384-1388. PMID: 9388126
25. Yu HH, Ginsburg GS, Harris N, Rifai N. (1997) Evaluation and clinical application of a direct low-density lipoprotein cholesterol assay in normolipidemic and hyperlipidemic adults. Am J Cardiol 80:1295-1299. PMID: 9388101
26. Satler CA, Vesely MR, Duggal P, Ginsburg GS, Beggs A. (1998) Multiple different missense mutations in the pore region of HERG in patients with long QT syndrome. Hum Genet. 102:265-272. PMID: 9544837
27. Jones P, Kafonek S, Laurora I, Hunnninghake D for the CURVES Investigators. (1998) Comparative dose efficacy study of Atorvastatin versus Simvastatin, Pravastatin, Lovastatin, and Fluvastatin in patients with hypercholesterolemia (The CURVES Study). Am J Cardiol 81: 582-587.
28. Rifai N, Douglas PS, O’Toole M, Rimm E, Ginsburg GS. (1999) Cardiac Troponin T and I, Electrocardiographic Wall-Motion Analyses and Ejection Fractions in Athletes Participating in the Hawaii Ironman Triathlon. Am J Cardio 83:1085-1089. PMID: 10190525
29. Yu HH, Ginsburg GS, O’Toole ML, Otvos JD, Douglas PS, Rifai N. (1999) Acute Changes in Serum Lipids in Triathletes as Assessed by Nuclear Magnetic Resonance Spectroscopy. Athero Throm Vasc Res 19:1945-1949. PMID: 10446075
30. Gauthier BR, Robb M, Gaudet F, Ginsburg GS, McPherson R. (1999) Characterization of a Cholesterol Response Element (CRE) in the Promoter of the CETP Gene that Interacts with Transcription Factors SREBP-1a, -2 and YY1. Journal of Lipid Research 40:1284-1293. PMID: 10393213
31. Ginsburg GS, O’Toole M, Rimm E, Douglas PS, Rifai N. (2001) Gender Differences in Exercise-Induced Changes in Sex Hormone Levels and Lipid Perioxidation in Athletes Participating in the Hawaii Ironman Triathlon. Clin Chim Acta 305:131-139. PMID: 11249932
32. Ginsburg GS and McCarthy JJ. (2001) Personalized Medicine and the Pharmaceutical Industry. Trends in Biotechnology. 19: 491-496 PMID: 11711191
33. Ross JS, Stagliano N, Donovan M, Breitbart R, Ginsburg GS. (2001) Atherosclerosis: a cancer of the blood vessels, Am J Clin Path 116 S97-107. PMID: 11993705
34. Loscalzo J, Balaban R, Becker L, Ginsburg GS, Hachinski H JV, Heistad D, Leinwand L, Lenfant C, Marban E, Olson E, et al. (2002) AHA Task Force on Strategic Research Direction. Circulation 106:e149. PMID: 11795276
35. Meyer JM, Ginsburg, GS. (2002) The Path to Personalized Medicine. Current Opinion in Chemical Biology, 6:434-438. PMID: 12133717
36. Ross, JS, Ginsburg, GS. (2003) The Integration of Molecular Diagnostics with Therapeutics: Implications for Drug Development and Pathology Practice. American Journal Clinical Pathology 19:26-36. PMID: 12465450
37. Ross, JS, Ginsburg, GS. (2003) Integration of Molecular Diagnostics with Therapeutics: Implications for Drug Discovery and Patient Care. Expert Rev Mol Diagn. 2:531-541. PMID: 12546952
38. Invanov GS, Kater JM, Jha SH, Stutius EA, Sabharwal R, Tricarico MD, Ginsburg, GS, Ozer JS. (2003) Sp and GATA factors are critical for Apolipoprotein AI downstream enhancer activity in human HepG2 cells. Gene. 24;323:31-42. PMID: 14659877
39. Ross JS, Schenkein DP, Pietrusko R, Rolfe M, Linette GP, Stec J, Stagliano NE, Ginsburg GS, Symmans WF, Pusztai L, et al. (2004) Targeted Therapies for Cancer. Am J Clin Pathol 122:598-609. PMID: 15487459
40. Jefferson BK, Foster JH, McCarthy JJ, Ginsburg GS, Parker A, Kottke-Marchant K, Topol EJ. (2005) Aspirin Resistance and a Single Gene. Am J Cardiol 95:805-808. PMID: 15757620
41. Febbo P and Ginsburg GS. (2005) Personalized Diagnostic and Therapeutic Strategies in Oncology. Personalized Medicine 2:97-110.
42. Seo D and Ginsburg GS. (2005) Genomic Medicine: Bringing biomarkers into clinical medicine. Cur Op Chem Biol. 9:381-386. PMID: 16006183
43. Willard H, Angrist M, Ginsburg GS. (2005) Genomic Medicine: Genetic variation and its impact on the future of health care. Phil Trans R Soc B 360:1543-1550. PMID: 16096102
44. Ginsburg GS, Donahue MP, Newby LK. (2005) Prospects for personalized cardiovascular medicine. The Impact of Genomics. J Am Coll Cardiol. 46:1615-1627. PMID: 16256859
45. Ginsburg GS, Konstance RP, Allsbrook JS, Schulman KD. (2005) Implications of Pharmacogenomics for Drug Development and Clinical Practice. Arch Intern Med 165:2331-2336. PMID: 16287761
46. Abrahams E, Ginsburg GS, and Silver M. (2005) The Personalized Medicine Coalition: Goals and Strategies. Am J Pharmacogenomics 5:345-355. PMID: 16336000
47. DeMaria AN, Ben-Yehuda O, Berman D, Feld GK, Ginsburg GS, Greenberg BH, Lew WYW, Sahn D. (2005) Highlights of the Year in JACC 2005. J Am Coll Cardiol 47:184-202. PMID: 16386685
48. Ginsburg GS and Haga S. (2006) Translating genomic biomarkers into clinically useful diagnostics. Expert Rev Mol Diagn. 5:179-191. PMID: 16512778
49. West M, Ginsburg GS, Huang AT, Nevins JR. (2006) Embracing the complexity of genomic data for personalized medicine. Genome Research. 16:559-566. PMID: 16651662
50. Ginsburg GS and Angrist M. (2006) The future may be closer than you think: A response from the Personalized Medicine Coalition to the Royal Society’s report on personalized medicine. Personalized Medicine. 3:119-123.
51. Cotten CM, Ginsburg GS, Goldberg RN, and Speer M. (2006) Genomic Analyses: A Neonatology Perspective. J. Pediatr 148:720-726. PMID: 16769375
52. Seo D, Ginsburg GS, and Goldschmidt-Clermont PJ. (2006) Gene expression analysis of cardiovascular diseases: Novel insights to biology and clinical applications. J Am Coll Cardiol 48:227-235. PMID: 16843168
53. Haga S and Ginsburg GS. (2006) Prescribing BiDil: is it black and white? J Am Coll Cardiol. 48:12-14. PMID: 16814642
54. Potti A, Mukherjee S, Petersen R., Dressman HK, Bild A, Koontz J, Kratzke R, Watson MA, Kelley M, Ginsburg GS, West M, Harpole DH, and Nevins JR. (2006) A genomic strategy to refine prognosis and therapeutic decision for adjuvant therapy in non-small cell lung carcinoma. N Engl J Med. 355:570-580. PMID: 16899777
55. Ginsburg GS and Freedman N. (2006) Novel – and “Neu” – therapeutic possibilities for heart failure. J Am Coll Cardiol. 48:1448-1450. PMID: 17010809
56. Stallings S, Witt W, Finkelstein S, Hiller A, Sinskey A, and Ginsburg GS. (2006) A Framework to Evaluate the Economic Impact of Pharmacogenomics. Pharmacogenomics 7:853-862. PMID: 16981846
57. Ginsburg GS, Angrist M, and Cook-Deegan R. (2006) Genomics and medicine at a crossroads in Chernobyl. Science 314:62-63. PMID: 17023637
58. Ginsburg GS, Seo D, and Frazier C. (2006) Microarrays coming of age in cardiovascular medicine: Standards, predictors and biology. J Am Coll Cardiol 48:1618-1620. PMID: 17045897
59. Potti A, Dressman HK, Bild A, Riedel RF, Chan G, Sayer R, Cragun J, Cottrill H, Kelley MJ, Petersen R, Harpole D, Marks J, Berchuck A, Ginsburg GS, Febbo P, Lancaster J, and Nevins JR. (2006) Genomic signatures to guide the use of chemotherapeutics. Nature Med 12:1294-1300. PMID: 17057710
60. DeMaria AN, Ben-Yehuda O, Feld GK, Ginsburg GS, Greenberg BH, Lew WYW, Lima JC, Maisel AS, Narula J, Sahn DJ, and Tsimikas S. (2007) Highlights of the year in JACC 2006. J Am Coll Cardiol. 49:509-527. PMID: 17258099
61. Luo A, Jefferson BK, Garcia MJ, Ginsburg GS, and Topol EJ. (2007) Challenges in the phenotypic characterization of patients in genetic studies of coronary artery disease. J Med Genet 44:161-165. PMID: 17158593
62. Dressman HK, Berchuck A, Chan G, Zhai J, Bild A, Sayer R, Cragun J, Clarke J, Whitaker RS, Li L, Gray J, Marks J, Ginsburg GS, Potti A, West M, Nevins JR, and Lancaster JM. (2007) An integrated genomic-based approach to personalized treatment of patients with advanced-stage ovarian cancer. J. Clin Oncol, 25:517-525. PMID: 17290060
63. Dressman H, Muramoto GG, Chao NJ, Ginsburg GS, Nevins JR, and Chute JP. (2007) Gene expression signatures that predict levels of radiation exposure. Plos Med 4: e106. PMID: 17407386
64. Ginsburg GS, Shah S, and McCarthy J. (2007) Taking cardiovascular genetic association studies to the next level. J Am Coll Cardiol 50:930-932. PMID: 17765118
65. Parker A, Ismailova ES, Narang J, Badola S, Roubenoff R, Ginsburg GS, Maier A, Shadick NA, and Weinblatt ME. (2007) Peripheral blood expression of nuclear factor-k-B-regulated genes is associated with rheumatoid arthritis disease activity and responds differentially to anti-tumor necrosis factor-alpha versus methotrexate. J Rheumatol, 34:1817-1822. PMID: 17696278
66. Lugogo NL, Ginsburg GS, and Que LG. (2007) Genetic profiling and tailored therapy in asthma: Are we there yet? Curr Opin Mol Ther 9:528-537. PMID: 18041663
67. Ginsburg GS. (2007) Regression of Atherosclerosis with Therapeutic Antibodies: Pipe Cleaner or Pipe Dream? J Am Coll Cardiol. 50:2319-2321. PMID: 18068041
68. Shadick NA, Heler JE, Weinblatt ME, Maher NE, Ginsburg GS, Cui J, Coblyn J, Anderson R, Solomon DH, Roubenoff R, and Parker A. (2007) Opposing effects of the D70 mutation and the shared epitope in HLA-DR4 on disease activity and certain disease phenotypes in rheumatoid arthritis. Annuals of Rheumatic Disease 66:1497-1502. PMID: 17491100
69. DeMaria AN, Bax JJ. Ben-Yehuda O. Clopton P, Feld GK, Ginsburg GS, Greenburg NH, Knoke JD,Lew WY, Lima JA, Maisel AS. Naravun , SM, Narula J, Sahn DJ, and Tsimikas S. (2008) Highlights of the year in JACC. J Am Coll Cardio 51:490-512. PMID: 18222362
70. Ginsburg GS, Burke T, and Febbo P. (2008) Centralized biorepositories for academic medical centers and health systems. JAMA 19:299, 1359-1350. PMID: 18349099
71. Aziz H, Zaas A, and Ginsburg GS. (2008) Peripheral Blood Gene Expression Profiling for Cardiovascular Disease Assessment. Genomic Med 1:105-112. PMID: 18923935
72. Douglas PS and Ginsburg GS. (2008) Clinical Genomic Testing: Getting it Right. J. Cardiovasc. Trans. Res. (1)17-20
73. Acharya C, Anders C, Hsu D, Anguiano A, Salter K, Walters K, Perez B, Mukherjee S, Barry W, Marcom KP, Ginsburg GS, Dressman H, Lyman G, Nevins JR, and Potti A. (2008) Genomic signatures complement clinico-pathologic risk stratification and provide individualized treatment options in early stage breast cancer. JAMA 299, 1574-1587 PMID: 18387932
74. Dressman H, Meadows SK, Muramoto G, Himburg H, Salter A, ZhengZheng W, Ginsburg GS, Chao N, Nevins J, and Chute J. (2008) Peripheral blood gene expression profiles are accurate, durable and specific at predicting radiation exposure versus other medical conditions. PLOS One 10:1371
75. Ginsburg GS. (2008) ‘Grand challenges’ in the translation of genomics to human health. European Journal of Human Genetics. 16,873-874. PMID: 18560443
76. Wingrove JA, Daniels SE, Sehnert AJ, Tingley W, Elashoff MR, Rosenberg S,Buellesfeld L, Grube E, Newby K, Ginsburg GS, and Kraus WE. (2008) Peripheral Blood Gene Expression Discriminates the Extent of Coronary Artery Stenosis. Circulation Cardiovascular Genetics 1:31-38
77. Califf RM, and Ginsburg GS. (2008) Organizational Improvements to Enhance Modern Clinical Epidemiology. JAMA 300:2300-2302. PMID: 19017917
78. Garman KS, Acharya CR, Edelman E, Grade M, Gaedcke J, Sud S, Mukherjee S, Ginsburg GS, Barry W, Diehl AM, Provenzale D, Hsu D, Ghadimi BM, Ried T, Nevins JR, and Potti A. (2008) A Genomic Approach to Colon Cancer Risk Stratification Yields Biologic Insights into Therapeutic Opportunities. Proc Natl Acad Sci 105:194361-19436. PMID: 19050079
79. Voora D, Shah S, Reed CR, Zhai J, Messer C, Salisbury BA, and Ginsburg GS. (2008) Pharmacogenetic predictors of statin mediated LDLc reduction and dose response. Circulation Cardiovascular Genetics 1:100-106.
80. Staples J, Cook-Deegan R, and Ginsburg GS. (2008) The role of the academic medical center in advancing personalized health care. In Personalized Health Care: Pioneers, Partnerships, Progress. Report prepared by the Initiative on Personalized Health Care, Department of Health and Human Services.
81. Shah SH, Freedman NJ, Zhang L, Crosslin DR, Stone DH, Haynes C, Johnson J, Nelson S, Wang L, Connelly J, Muehlbauer M, Ginsburg GS, Crossman DC, Jones CJH, Vance J, Sketch M, Granger CB, Newgard CB, Gregory SG, Goldschmidt PJ, Kraus WE, and Hauser ER. (2009) Neuropeptide Y Gene Polymorphisms Confer Risk of Early-onset Atherosclerosis. PLoS Genet.5(1):e1000318. PMID: 19119412
82. Kawamoto K, Lobach DF, Willard HF, and Ginsburg GS. (2009) National clinical decision support infrastructure to enable the widespread and consistent application of genetics and genomics in healthcare. BMC Medical Informatics and Clinical Decision Making. 9:17. PMCID: PMC2666673
83. Shah SH, Hauser ER, Bain JR, Muehlbauer MJ, Stevens RD, Wenner BR, Sketch M, Dowdy E, Granger GB, Ginsburg GS, Newgard CB, and Kraus WE. (2009) High heritability of metabolomic profiles in families burdened with early-onset cardiovascular disease. Mol Syst Biol, 5:258 PMID: 19357637.
84. Broadfoot MV, and Ginsburg GS. (2009) The Center for Genomic Medicine at the Duke Institute for Genome Sciences & Policy: Propelling Genomics into Clinical Practice. Personalized Medicine 6:255-261
85. Zaas A, Chen M, Varkey J, Veldman T, Hero III AO, Lucas J, Huang Y, Turner R, Gilbert A, Lambkin-Williams R, Oien NC, Nicholson B, Kingsmore S, Carin L, Woods CW, and Ginsburg GS. (2009) Gene Expression Signatures Diagnose Influenza and Other Symptomatic Respiratory Viral Infections in Humans. Cell Host & Microbe. 6:1-11
86. Eagle KA, Ginsburg GS, Musunuru K, Aird WC, Balaban RS, Bennett SK, Blumenthal RS, Coughlin SR, Davidson KW, Frohlich ED, Greenland P, Jarvik GP, Libby P, Pepine CJ, Ruskin JN, Stillman A, Van Eyk JE, Tolunay HE, McDonald CL, and Smith SC. (2009) Identifying Patients at high risk of a cardiovascular event in the near future: Current Status and Future Directions – Report of a National Heart, Lung, and Blood Institute Working Group. Circulation AHA 2009/904029
87. Voora D, Shah SH, Spasojevic I, Ali S, Reed CR, Salisbury, BA, and Ginsburg GS. (2009) The SLCO1B1*5 Genetic Variant is Associated with Statin-Induced Side Effects. J Amer Coll Card. In Press.
88. Khoury, MJ, McBride C, Schully SD, Ioannidis JPA, Feero WG, Cecile A, Janssens JW, Gwinn M, Simons-Morton DG, Avey LS, Bernhardt JM, Cargill M, Chanock SJ, Church GM, Coates RJ, Collins FS, Croyle RT, Davis BR, Downing GJ, DuRoss A, Friedman S, Gail MH, Ginsburg GS, Green RC, Greene MH, Greenland P, Gulcher JR, Hsu A, Hudson KL, Kardia SLR, Kimmel PL, Lauer MS, Miller AM, Offit K, Ransohoff DF, Roberts S, Rasooly RS, Stefansson K, Terry SF, Trepanier A, Wanke KL, Witte JS, and Xu J. (2009) The Scientific Foundation for Personal Genomics: Recommendations from an NIH-CDC Multidisciplinary Workshop. Genetics in Medicine. In Press.
89. Shah SH, Bain JR, Crosslin DR, Muehlbauer MJ, Stevens RD, Haynes C, Dungan J, Newby LK, Hauser ER, Ginsburg GS, Newgard CB, and Kraus WE. (2009) Association of a Peripheral Blood Metabolic Profile with Coronary Artery Disease and Risk of Subsequent Cardiovascular Events. Circulation Cardiovascular Genetics. In Press
90. Kawamoto K, Orlando LA, Voora D, Lobach DF, Joy S, Cho A, and Ginsburg GS. (2009) Evaluation of the PharmGKB Knowledge base as a resource for efficiently assessing the clinical validity and utility of pharmacogenetic assays. Journal of the American Medical Informatics Association. In Press
91. Voora D, and Ginsburg GS. (2009) Genetics of Statin Response. Current Cardiovascular Risk Reports. In Press
92. Chiba-Falek O, Nichols M, Succhindran S, Guyton J, Ginsburg GS, Barrett-Connor E, McCarthy JJ. (2009) Impact of gene variants on sex-specific regulation of human scavender receptor class B type 1 (SR-BI) expression in liver and association with lipid levels in a population-based study. BMC Medical Genetics. Submitted.
93. Chen M, Carlson C, Zaas A, Woods CW, Ginsburg GS, Hero III AO, Lucas J, and Carin L. (2009) The Bayesian Elastic Net: Classifying Multi-Task Gene-Expression Data. IEEE Trans. Signal Processing. Submitted
94. Sinnaeve PR, Donahue MP, Grass P, Seo D, Vonderscher J, Chibout SD, Kraus WE, Sketch M, Nelson C, Ginsburg GS, Goldschmidt-Clermont PJ, and Granger GB. (2009) Gene expression patterns in peripheral blood correlate with the extent of coronary artery disease and mirror expression profiles in atherosclerotic arteries. Submitted.
95. Voora D, Ortel TL, Lucas J, Chi JT, Becker RC, Ginsburg GS. (2009) A comprehensive assessment to integrate multiple measures of indirect COX-1 platelet function to measure the response to aspirin. Submitted
96. Chen M, Chen B, Paisley J, Zaas, A, Woods CW, Ginsburg GS, Hero III A, Lucas J, Dunson D, and Carin L. (2009) Non-Parametric Bayesian Factor Analysis: Application to Time-Evolving Viral Gene-Expression Data. In Preparation
Books
1. Willard HF, and Ginsburg GS (2009) Genomic and Personalized Medicine, Volumes 1 and 2, Elsevier, Philadelphia.
2. Ginsburg GS and Willard HF (2009) Essentials in Genomic and Personalized Medicine, Elsevier, Philadelphia (In Press)
Non-Refereed Publications:
1. Ginsburg GS, and Pasternak RC. (1992) Low High Density Lipoprotein Cholesterol Levels in Patients with Desirable Total Cholesterol Levels. Cardiol Board Rev. 9:83-93.
2. Ginsburg GS and Pasternak RC. (1994) Drug Management of Atherosclerosis. J. Crit. I11 9:9931024.
3. Douglas PS and Ginsburg GS. (1998) Diagnosing Cardiac Chest Pain. Women’s Health Primary Care 1:183-195.
4. Douglas PS and Ginsburg GS. (1998) Diagnosing Cardiac Chest Pain. Women’s Health Orthopedic Edition 1:11-18.
5. Yu HH, Pasternak RC, and Ginsburg GS. (2000) Lipid Management for Patients with CAD: A Guide to Drug Therapy. J. Crit. I11 15:5-6.
6. Dean NJ, Duyk G, and Ginsburg GS, Kamb A, Arcaris; Mous J, and Szymkowski D. (2000) Target Identification and Validation: Key Approaches for Improving the Efficiency and Profitability of Drug Discovery and Development.
7. Ross JS, Stagliano NE, Donovan MJ, Breitbart RE, and Ginsburg GS. (2001) Atherosclerosis and Cancer: Common Molecular Pathways of Disease Development and Progression. Ann NY Acad Sci. 947:271-292.
8. Ross JS and Ginsburg, GS. (2002) Integrating Diagnostics and Therapeutics: Revolutionizing Drug Discovery and Patient Care. Drug Discovery Today 859-864.
9. Trepicchio WL, and Ginsburg GS. (2004) Microarrays: Enabling Smarter Drugs and Personalized Medicines. Regulatory Affairs Focus. 8:46-49.
10. Ginsburg GS and Shah SH. (2006) Genetic and Genomic Testing in Cardiovascular Disease. Biomedical Research and Education Foundation. 11:1-4.
11. Ginsburg, GS (2008) Genomic and Personalized Medicine, Medscape
12. Ginsburg GS and McCarthy JJ. (2009) Transforming the Practice of Medicine Using Genomics. Bone and Mineral Metabolism – Pharmacogenetics. 6:25-28
Non-Refereed Internal Documents at Millennium Pharmaceuticals, Inc.:
1. Ginsburg GS, and Lohmer S. (1998) Bayer-Millennium High Throughput Small Molecule Drug Discovery Research Plan. Millennium Pharmaceuticals, Inc. Internal Millennium and Bayer White Paper.
2. Ginsburg GS, and Nemetz SN. (2002) The Personalized Medicine Business Plan for 2003-2004. Millennium Pharmaceuticals, Inc. Internal Millennium White Paper.
3. Ginsburg GS, and Kucherlapti R. (2004) The National Centers for Clinical Discovery. A White Paper. Millennium Pharmaceuticals, Inc. and Partners HealthCare System. Internal Millennium and Partners Healthcare White Paper.
Book Chapters:
1. Ginsburg GS. (1978) The electrochemical and mercury promoted reduction of aa’-dibromo-bicycloalkanones. B.A. Honors Thesis, Wesleyan University, Middletown, CT.
2. Small DM, Miller K, Cistola D, Ginsburg GS, Parks J, Atkinson D, and Hamilton JA. (1983) Physicochemical studies on the position of molecules in emulsions and membranes. (In: Paumgartner G, Stiehl A., Gerok W, eds. Proceedings of the VI Intl Bile Acid Meeting Basel, October 1982). MTP Press Ltd., 5:25-30.
3. Ginsburg GS. (1984) Lipid-Lipid and Lipid-Protein interactions in model systems of low density lipoproteins. Ph.D. Thesis, Boston University School of Medicine, Boston, MA.
4. Rodriguez O, Braun LT, Rosenson RD, and Ginsburg GS. (1996) Components of cardiac rehabilitation and exercise prescription. In: Rose BD, ed. Up-To-Date Publishing Co., Wellesley, MA.
5. Ginsburg GS, Douglas PS, and Poppas A. (1996) Determinants and management of cardiovascular risk in women. In: Rose BD, ed. Up-To-Date Publishing Co., Wellesley, MA.
6. Ginsburg GS, Rosen HN, Tangney CC, and Rosenson RS. (1996) Estrogen replacement therapy and cardiovascular risk. In: Rose BD, ed. Up-To-Date Publishing Co., Wellesley, MA.
7. Ginsburg GS. (1996) Efficacy of cardiac rehabilitation after myocardial infarction. In: Rose BD, ed. Up-To-Date Publishing Co., Wellesley, MA.
8. Ross JS, and Ginsburg, GS. (2005) The integration of molecular diagnostics with therapeutics: implications for drug development and pathology practice. In: Adams, Julian., Proteasome. Humana Press.
9. Ginsburg GS. and Roubenoff R. (2006) CRP, Atherothrombosis and Cardiovascular Risk. Novel anti-inflammatory drug therapy. MediEdition 295-306.
10. Ginsburg GS. Lekstrom-Himes J, and Trepicchio W. (2006) Optimizing the “Drug-Like” Properties of Leads in Drug Discovery. Optimizing biomarker development for clinical studies at the lead optimization stage of drug development. Springer Publishing 411-422.
11. Ginsburg GS. (2009) Translational Genomics: From Discovery to Clinical Practice in Genomic and Personalized Medicine, Willard HF, Ginsburg GS, eds; Elsevier, Philadelphia.
12. Marcom PK, Anders CK, Ginsburg GS, Nevins JR, and Potti A. (2008) Utilization of genomic signatures for personalized treatment of breast cancer. In: “Pharmacogenetics of Breast Cancer,” MacMillian Publishing Solutions.
13. Ginsburg GS. (2009) “Translational Genomics” In Essentials of Genomic and Personalized Medicine, Ginsburg GS, Willard HF, (eds),Elsevier, Philadelphia.
14. Ginsburg GS. Willard, HF. (2009) “The Foundations of Genomic and Personalized Medicine” in Essentials of Genomic and Personalized Medicine,” Ginsburg GS, Willard HF (eds), Elsevier, Philadelphia.
Contact Information
Geoffrey S. Ginsburg
Phone: 919-668-6210
2111 CIEMAS
Email
Assistant to Dr. Ginsburg
Rita L. Chambers
Phone: 919-668-6210
2117 CIEMAS